June 2023 ASCO update:
In a review of 8 clinical trials (N=513), immune checkpoint inhibitors (ICIs) including cemiplimab, pembrolizumab and nivolumab were effective in the treatment of resectable, locally-advanced, and metastatic cutaneous squamous cell carcinoma (cSCC).1 ICIs were also shown to be safe and effective in the real-world cSCC setting, with patients showing response independent of age, comorbidities, or Eastern Cooperative Oncology Group (ECOG) performance status.2 The NEO-CESQ study showed that neoadjuvant plus adjuvant treatment with cemiplimab in surgically resectable, high risk stage III/IV (M0) cSCC induced a pathological response in 52% of the patients with a major pathological response rate of 48%.3

  1. Anwar M, et al. Immune checkpoint inhibitors in cutaneous squamous cell carcinoma: a systematic review of clinical trials. J Clin Oncol. 2023;41(suppl 16); Abstract e21529.
  2. Koch Hein EC, et al. Immune checkpoint inhibitors in advanced cutaneous squamous cell carcinoma: real-world evidence. J Clin Oncol. 2023;41(suppl 16); Abstract e21519.
  3. Ascierto P, et al. NEO-CESQ study: neoadjuvant plus adjuvant treatment with cemiplimab in surgically resectable, high risk stage III/IV (M0) cutaneous squamous cell carcinoma. J Clin Oncol. 2023;41(suppl 16); Abstract 9576.

Targeting Tumors with High Mutational Burden: Treating Patients with Advanced Non-Melanoma Skin Cancers

FACULTY

Reinhard Dummer, MD
Professor and Vice Chairman
Department of Dermatology
University of Zurich Hospital
Zurich, Switzerland

Michael R. Migden, MD
Professor
Department of Dermatology and Department of Head and Neck Surgery
Division of Internal Medicine
University of Texas MD Anderson Cancer Center
Houston, TX

Vishal A. Patel, MD
Director of Cutaneous Oncology
Director of Dermatologic Surgery
Associate Professor of Dermatology and Medicine/Oncology
George Washington University School of Medicine & Health Sciences
Washington, DC

PROGRAM DESCRIPTION

This enduring activity will increase the target clinician’s knowledge base on new systemic immune therapies for the treatment of patients with non-melanoma skin cancer (NMSC); enhance their ability to identify and manage side effects associated with new immunotherapies for the treatment of patients with advanced basal cell carcinoma or cutaneous squamous cell carcinoma; and improve their ability to coordinate care and cooperation across the multidisciplinary care team to optimize outcomes in patients with NMSC.

TARGET AUDIENCE

This activity is designed to meet the educational needs of global oncologists, dermatologists, Mohs surgeons, and the multidisciplinary care team who care for patients with advanced or metastatic basal cell or cutaneous squamous cell carcinomas.

LEARNING OBJECTIVES

  • Incorporate immune checkpoint inhibitor therapy data into the management of patients with metastatic or locally advanced cutaneous squamous cell carcinoma
  • Review the immune therapy data for patients with either metastatic or locally advanced basal cell carcinoma in the second-line setting
  • Recognize and manage the treatment related adverse events associated with immune checkpoint inhibitor therapy in patients with non-melanoma skin cancers
  • Describe the multidisciplinary team approach in the management of patients with locally advanced or metastatic basal cell or cutaneous squamous cell carcinomas

ACCREDITATION STATEMENT

Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. This CME activity was planned and produced in accordance with the ACCME Essentials.

PHYSICIAN CREDIT DESIGNATION STATEMENT

Med Learning Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.

JOINT ACCREDITATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Amedco LLC and Med Learning Group. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


NURSES (ANCC) CREDIT DESIGNATION

Amedco LLC designates this activity for a maximum of 1.0 ANCC contact hour.

DISCLOSURE POLICY STATEMENT

In accordance with the Accreditation Council for Continuing Medical Education ACCME Standards for Integrity and Independence in Accredited Continuing Education, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIP(S)

Dr. Dummer has intermittent, project focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dhome (MSD), Bristol-Myers Squibb (BMS), Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, Catalym, Second Genome, Regeneron, Alligator, T3 Pharma, MaxiVAX SA, Pfizer, and touchlME outside the submitted work.

Dr. Migden has received consulting fees from Regeneron, Replimune, Sun Pharmaceuticals, and Stamford Pharmaceuticals.

Dr. Patel has received consulting fees from Regeneron, Sanofi, PhD Biosciences, Almirall, and Jounce Therapeutics. He is on the Speakers Bureau for Regeneron, Sanofi, and Almirall, and has ownership interests in Avstera Therapeutics, Lazarus AI, and Science 37.

All relevant financial relationships have been mitigated.

CME Content Review

The content of this activity was independently peer reviewed.
The reviewer of this activity has nothing to disclose.

CNE Content Review

The content of this activity was peer reviewed by a nurse reviewer.
The reviewer of this activity has nothing to disclose.

Staff, Planners and Managers

The staff, planners, and managers reported the following financial relationships or relationships to products or devices they partner have with ineligible companies related to the content of this CME/CE activity:

  • Matthew Frese, General Manager of Med Learning Group has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group has nothing to disclose.
  • Chris Drury, MA, MS, MBA, Medical Director for Med Learning Group, has nothing to disclose.
  • Lauren Welch, MA, VP, Outcomes and Accreditation for Med Learning Group has nothing to disclose.
  • Russie Allen, Accreditation and Outcomes Manager for Med Learning Group has nothing to disclose.
  • Felecia Beachum, Program Manager for Med Learning Group has nothing to disclose.
  • Naomi De Brito, Program Coordinator for Med Learning Group has nothing to disclose.

DISCLOSURE OF UNLABELED USE

Med Learning Group requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States. During the course of this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.

METHOD OF PARTICIPATION

There are no fees for participating and receiving CME/CNE credit for this enduring activity. To receive CME/CNE credit participants must:

  1. Read the CME/CNE information and faculty disclosures
  2. Participate in the enduring activity
  3. Complete and submit the evaluation form to Med Learning Group

You will receive your certificate after the enduring activity.

DISCLAIMER

Med Learning Group makes every effort to develop CME activities that are scientifically based. This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making expertise before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact Med Learning Group at [email protected]

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information athttps://www.medlearninggroup.com/privacy-policy/

AMERICANS WITH DISABILITIES ACT

Event staff will be glad to assist you with any special needs. Please contact Med Learning Group at [email protected]

RELEASED DATE: May 31, 2023
EXPIRATION DATE: May 31, 2024

Copyright © 2023 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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This award is both an honor and a testament to our cumulative dedication to providing the best continuing medical education (CME) services to HCPs across the globe. We are proud to be part of this distinguished group and look forward to continuing to have MLG be one of the best CME providers in the country.

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