Insights to Improve Responses to Immunotherapies: A Simulation Center Approach to Identifying Patients Who May Benefit from Predictive Biomarkers


Kurt Schalper, MD, PHD
Associate Professor of Pathology
Director, Translational Immuno-oncology Laboratory
New Haven, CT

Liza Villaruz, MD
Associate Professor of Medicine
UPMC Hillman Cancer Center
Pittsburgh, PA


This simulated activity depicts conversations between an oncologist, a pathologist, and a patient diagnosed with non-small cell lung cancer (NSCLC). You will watch as they engage with each other throughout the various stages of a patient’s journey, from the initial pathologic and oncologic workup at initial presentation to disease recurrence. You will participate in the simulation by answering questions throughout the activity. A brief slide presentations is available within each simulation center activity to enhance your understanding of immunological biomarkers.


This activity is intended for medical oncologists, pathologists, cytotechnologists, researchers, and other healthcare and laboratory professionals interested in immuno-oncology, precision medicine, and/or biomarker research.


Upon the completion of this program, attendees should be able to:

  • Summarize the utility of predicative immune-related biomarkers for the treatment of patients with cancer
  • Evaluate the challenges and limitations associated with predictive biomarker testing for patients with cancer eligible for treatment with immunotherapies
  • Cite relevant data concerning patients with cancer most likely to benefit from immunotherapies through the incorporation of predictive biomarker testing in routine clinical practice


Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. This CME activity was planned and produced in accordance with the ACCME Essentials.


Med Learning Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.


Purpose: Education regarding the management of VTE in cancer leads to safe practices, quality care, and continued professional and personal development for oncology nurses.

CNE Credits: 1.0 ANCC Contact Hour.


Ultimate Medical Academy/CCM is accredited as a provider of nursing continuing professional education development by the American Nurses Credentialing Center’s Commission on Accreditation.

Awarded 1.0 contact hour of continuing nursing education of RNs and APNs.


In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.


Kurt Schalper, MD, is on salary for Yale University and is a consultant for AbbVie, AstraZeneca, Celgene, Clinica Alemana de Santiago, Dynamo Therapeutics, Fluidigm, Moderna Therapeutics, Ono Pharmaceuticals, Pierre-Fabre, Shattuck Labs, EMD Serono, Takeda, Torque Therapeutics, Agenus, Genmab, Bristol-Myers Squibb, and Merck. He has done research for AstraZeneca, Bristol Myers Squibb, Merck, Moderna Inc., Navigate Biopharma (Novartis), Pierre-Fabre Research Institute, Surface Oncology, Takeda, Tesaro/GSK, Ribon Therapeutics, Eli Lilly, Akoya Biosciences, and Boehringer-Ingelheim.

Liza Villaruz, MD is a consultant for Bristol-Myers Squibb, Daiichi Sankyo, Janssen, Jazz, and Takeda.

CME Content Review

The content of this activity was independently peer reviewed.
The reviewer of this activity has nothing to disclose.

CNE Content Review

The content of this activity was peer reviewed by a nurse reviewer.

Douglas Cox, MSN, MHA, RN
Ultimate Medical Academy/CCM – Lead Nurse Planner

The reviewer of this activity has nothing to disclose

Staff Planners and Managers

The staff, planners, and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

  • Matthew Frese, MBA, General Manager of Med Learning Group, has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group, has nothing to disclose.
  • Angela Davis, PhD, Medical Director for Med Learning Group, has nothing to disclose.
  • Lauren Welch, MA, VP, Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Douglas Cox, MSN, MHA, RN, UMA/CCM – LNP, has nothing to disclose.
  • Melissa Johnson, Senior Program Manager for Med Learning Group, has nothing to disclose.
  • Amanda Jenkins, Program Manager for Med Learning Group, has nothing to disclose.
  • Natalie Smith, Program Coordinator for Med Learning Group, has nothing to disclose.
  • Aimee Meissner, Accreditation and Outcomes Coordinator for Med Learning Group, has nothing to disclose.


Med Learning Group requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.


There are no fees for participating and receiving CME credit for this enduring activity. To receive CME/CNE credit participants must:

  1. Read the CME/CNE information and faculty disclosures.
  2. Participate in the activity.
  3. Complete pre-and-post surveys and evaluation.

You will receive your certificate as a downloadable file.


Med Learning Group makes every effort to develop CME activities that are science based.

This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision making before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact Med Learning Group at [email protected].

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information at


Staff will be glad to assist you with any special needs. Please contact Med Learning Group prior to participating at [email protected].

Copyright © 2022 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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Med Learning Group, a division of Ultimate Medical Academy, is a full-service accredited medical education company with commendation. Med Learning Group focuses on developing and implementing continuing education that improves healthcare practitioners’ ability to provide optimal care to their patients. Our goal is to provide high-quality education that is designed to deliver the highest level of outcomes for not only the practitioner, but also the patient. Med Learning Group has expertise in developing both live and online activities that are innovative, case-based, interactive and patient-centric in nature.

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