Considerations in the Evaluation of Real-World Evidence for Patients with Multiple Myeloma: Efficacy and Safety Considerations to Inform Therapy


Amrita Krishnan, MD
Director of the Judy and Bernard Briskin Center for Multiple Myeloma Research
Professor, Department of Hematology & Hematopoietic Cell Transplantation
Chief, Division of Multiple Myeloma
Department of Hematology and Hematopoietic Cell Transplantation
City of Hope Cancer Center
Duarte, CA


This enduring TeleECHO program will explore the role of real-world evidence in informing management decisions of elderly and frail patients with relapsed and refractory multiple myeloma (RRMM). A brief didactic presentation will discuss prognostic features and key management considerations for the elderly and frail patient populations. A summary of clinical trial data and real world evidence to inform treatment selection in the first-line and relapse settings will also be presented. Interactive case studies will illustrate strategies for patient counseling and treatment selection in elderly and frail patients with RRMM.


This activity is designed to meet the educational needs of medical oncologists, hematologists, nurse practitioners, pharmacists, and other members of the multidisciplinary oncology care team.


Upon the completion of this program, attendees should be able to:

  • Evaluate considerations in the management of multiple myeloma in elderly and frail populations, including features of the prognosis and prognostic evaluation of these patients
  • Summarize clinical trial outcomes and the role of real-world evidence in informing treatment decisions in patients who are less likely to be considered for clinical trial enrollment
  • Analyze clinical trial outcomes and real-world evidence to inform patient counseling and treatment decisions in frail and elderly patients with multiple myeloma


Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

This CME activity was planned and produced in accordance with the ACCME Essentials.


Med Learning Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the online activity.


Purpose: This program would be beneficial for nurses involved in the care of patients with multiple myeloma.
CNE Credits: 1.0 ANCC Contact Hour.


Ultimate Medical Academy/Complete Conference Management (CCM) is accredited as a provider of nursing continuing professional education development by the American Nurses Credentialing Center’s Commission on Accreditation.

Awarded 1.0 contact hour of continuing nursing education of RNs and APNs.


In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.


Dr. Krishnan has received consulting fees from Bristol Myers Squibb, GlaxoSmithKline, Pfizer, Janssen, Sanofi, Sutro Biopharma, Inc. and zPREDICTA; she has also served on the speakers’ bureau for Amgen, Bristol Myers Squibb, and GlaxoSmithKline. She holds stock in Bristol Myers Squibb and serves on the scientific advisory board for Sutro Biopharma, Inc. and zPREDICTA.

CME Content Review

The content of this activity was independently peer reviewed.
The reviewer of this activity has nothing to disclose.

CNE Content Review

The content of this activity was peer reviewed by a nurse reviewer.

Douglas Cox, MSN, MHA, RN
Ultimate Medical Academy/CCM – Lead Nurse Planner

The reviewer of this activity has nothing to disclose.

Staff Planners and Managers

The staff, planners, and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

  • Matthew Frese, MBA, General Manager of Med Learning Group, has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group, has nothing to disclose.
  • James Seternus, DO, Medical & Scientific Services for Med Learning Group has nothing to disclose.
  • Lauren Welch, MA, VP, Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Jessica McMullen, MPH, Program Manager for Med Learning Group, has nothing to disclose.
  • Russie Allen, Accreditation and Outcomes Manager for Med Learning Group, has nothing to disclose.
  • Douglas Cox, MSN, MHA, RN, UMA/CCM – LNP, has nothing to disclose.


Med Learning Group requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.


There are no fees for participating and receiving CME credit for this enduring activity. To receive CME/CNE credit participants must:

  1. Read the CME/CNE information and faculty disclosures.
  2. Participate in the online activity.
  3. Complete the online post-test and evaluation.

You will receive your certificate as a downloadable file.


Med Learning Group makes every effort to develop CME activities that are science based. This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision making before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact Med Learning Group at [email protected]

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information at


Staff will be glad to assist you with any special needs. Please contact Med Learning Group prior to participating at [email protected]


Copyright © 2022 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

Scroll to Top

A Special Thank You to All HCPs

Med Learning Group sends its heartful gratitude to all healthcare professionals giving their all, 24/7, during this pandemic, despite the great risks they face. We cannot thank you enough for your courage and selfless service.

Connecting you with our personalized approach to continuing Medical Education

The Linking Approach to Education from Gap Analysis to Outcomes

Med Learning Group, a division of Ultimate Medical Academy, is a full-service accredited medical education company with commendation. Med Learning Group focuses on developing and implementing continuing education that improves healthcare practitioners’ ability to provide optimal care to their patients. Our goal is to provide high-quality education that is designed to deliver the highest level of outcomes for not only the practitioner, but also the patient. Med Learning Group has expertise in developing both live and online activities that are innovative, case-based, interactive and patient-centric in nature.

Med Learning Group has expertise in developing both live and online activities that are innovative, case-based, interactive and patient-centric in nature, and we focus on applying adult learning theory and principles to our programs. Even more importantly, we understand the nuances of our target audiences and design programs with a grounded understanding of how to educate both specialty audiences and general practitioners.