Clinical Updates in Postpartum Depression Management:
Integrating Novel Therapeutics Targeting GABA-A in Practice


Anita Clayton, MD
Chair of Psychiatry and Neurobehavioral Sciences
Wilford W. Spradlin Professor
University of Virginia School of Medicine
Charlottesville, Virginia

Jennifer Payne, MD
Professor and Vice Chair of Research
Department of Psychiatry and Neurobehavioral Sciences
University of Virginia School of Medicine
Charlottesville, Virginia


The goal of this CME program is to enhance healthcare practitioner awareness of the burden of postpartum depression, as well as the need for novel mechanism in the management of postpartum depression; clinical data concerning therapeutic agents for postpartum depression targeting GABA-A receptors; as well as evolving management approaches in postpartum depression, including best practices for integration in current treatment paradigms.


This activity is designed to meet the educational needs of US-based obstetrician-gynecologists, community-based practitioners, nurse practitioners, midwives, and psychiatrists concerning the identification and management of postpartum depression.


Upon the completion of this program, attendees should be able to:

  • Evaluate the burdens of postpartum depression in consideration of gaps in management and opportunities to address gaps through novel mechanisms
  • Summarize the clinical efficacy and safety data informing the use of extrasynaptic GABA-A receptor allosteric modulators in the management of postpartum depression
  • Describe best practices and practical considerations in integrating GABA-A receptor allosteric modulators for the management of postpartum depression


In support of improving patient care, Med Learning Group is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Med Learning Group designates this enduring activity for a maximum of 1.5 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.


Med Learning Group designates this enduring activity for a maximum of 1.5 ANCC contact hours.


In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.


Faculty Member Disclosures
Anita Clayton, MD Discloses that she has received royalties from Ballantine Books, Changes in Sexual Functioning Questionnaire (CSFQ), and Guilford Publications. She has stock or stock options in Mediflix and S1 Biopharma. She has received consulting fees from AbbVie, Biogen, Brii Biosciences, Fabre-Kramer Pharmaceuticals, Initiator Pharma, Janssen Research & Development, PureTech Health, Reunion Neuroscience, S1 Biopharma, Sage Therapeutics, Sirtsei Pharmaceuticals, Vella Bioscience, and WCG MedAvante-ProPhase. She has received research funds from Daré Bioscience, Janssen, Neumora Therapeutics, Otsuka America Pharmaceutical, Relmada Therapeutics, and Sage Therapeutics.
Jennifer Payne, MD Discloses that she has received royalties from UpToDate and Elsevier. She holds two patents: Epigenetic Biomarkers of Postpartum Depression and Epigenetic Biomarkers of PMDD and SSRI Response. She has received consulting fees from Sage Therapeutics, Biogen, Flo Health, Pure Tech Health, Brii Biosciences, and Merck & Co. She has received research funds from Janssen Pharmaceuticals. She owns stock in Dionysus Digital Health.

All relevant financial relationships have been mitigated.

Content Review

The content of this activity was independently peer reviewed by a physician and nurse reviewer.

Individuals in Control of the Content of the Activity

The individuals in control of the content of this activity have reported the following financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CE activity:

  • Matthew Frese, MBA, General Manager of Med Learning Group, has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group, has nothing to disclose.
  • Kelly Vicci, RN, BSN, has nothing to disclose.
  • A medical reviewer from CME Peer Review LLC, has nothing to disclose.
  • Chris Drury, PhD, Medical Director for Med Learning Group, has nothing to disclose.
  • Lauren Welch, MA, VP, Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Andi Koral, MS, CMP, Program Manager for Med Learning Group, has nothing to disclose.
  • Aimee Meissner, Accreditation and Outcomes Coordinator, has nothing to disclose.


Med Learning Group requires that faculty participating in any CE activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.
During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.


There are no fees for participating and receiving CE credit for this activity.

In order to obtain your certificate for the mentioned accreditation, participants need to successfully complete the associated pre/post activities and evaluation.

Your certificate will be provided as a downloadable file.


Med Learning Group makes every effort to develop CE activities that are science-based. This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision making before applying any information, whether provided here or by others, for any professional use.

For CE questions, please contact Med Learning Group at [email protected]

Contact this CE provider at Med Learning Group for privacy and confidentiality policy statement information at


Staff will be glad to assist you with any special needs. Please contact Med Learning Group prior to participating at [email protected]

RELEASED DATE: May 30, 2024

Copyright ©2024 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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