Advancing Stroke Care: Understanding FXIa, Novel Therapies, and Patient-Centered Management

PROGRAM CHAIR

Manesh R. Patel, MD
Chief, Division of Cardiology
Vice President, Heart and Vascular Services
Duke University
Durham, North Carolina

PROGRAM OVERVIEW

This Educational Snapshot Activity is designed to address the learning needs of healthcare providers who manage patients at risk for stroke recurrence. The program clarifies the role of factor XIa (FXIa) in thrombus formation and stroke initiation, highlighting its potential as a therapeutic target. It presents emerging clinical evidence supporting FXIa-targeted novel oral therapies for secondary stroke prevention and emphasizes the need for antithrombotic options with reduced bleeding risk. Additionally, the activity promotes the application of patient-centered, evidence-based strategies for the long-term management of individuals at risk for stroke recurrence, in alignment with current clinical guidelines.

TARGET AUDIENCE

This activity is designed to meet the educational needs of U.S.-based neurologists, primary care physicians, critical care physicians, hospitalists, advanced practice providers, nurse practitioners, and pharmacists, and other allied health professionals involved in the management of patients that have experienced noncardioembolic ischemic stroke, or high-risk TIA.

LEARNING OBJECTIVES

Upon the completion of this program, attendees should be able to:

  • Explain the multifaceted role of FXIa in thrombus formation and the initiation of stroke, including its underlying pathophysiology
  • Evaluate emerging clinical evidence supporting novel oral small-molecule agents targeting FXIa for reducing stroke recurrence
  • Apply evidence-based, patient-focused approaches to managing individuals who have experienced non-cardioembolic ischemic stroke

JOINT ACCREDITATION STATEMENT

In support of improving patient care, Med Learning Group is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


PHYSICIAN CREDIT DESIGNATION STATEMENT

Med Learning Group designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.

NURSES (ANCC) CREDIT DESIGNATION

Med Learning Group designates this activity for a maximum of 0.75 ANCC contact hour.

DISCLOSURE POLICY STATEMENT

In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Integrity and Independence in Accredited Continuing Education, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS

Speaker Relationships Manufacturer
Manesh R. Patel, MD Contracted research Bayer Healthcare

All relevant financial relationships have been mitigated.

Content Review

The content of this activity was independently peer reviewed by a physician and nurse reviewer.

Individuals in Control of the Content of the Activity

The individuals in control of the content of this activity have reported the following financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CE activity:

  • Matthew Frese, MBA, CEO of Med Learning Group, has nothing to disclose.
  • Lauren Welch, MA, Sr VP of Operations for Med Learning Group, has nothing to disclose.
  • Sharine Griggs, Senior Program Manager for Med Learning Group, has nothing to disclose.
  • Tom Bregartner, MBA, VP of Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Caitlin Rothermel, MPH, Medical Director for Med Learning Group has nothing to disclose.
  • Arpan Patel, MD, an independent reviewer for Med Learning Group, has nothing to disclose.
  • Dominique Barton, B.S. BSN, has nothing to disclose.
  • A medical reviewer from CME Peer Review LLC, has nothing to disclose.
  • Daniel Dasilva, Accreditation and Outcomes Coordinator for Med Learning Group, has nothing to disclose.
  • Emmanuella Foucault, Associate Program Manager for Med Learning Group, has nothing to disclose.

DISCLOSURE OF UNLABELED USE

Med Learning Group requires that faculty participating in any CE activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States. During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.

METHOD OF PARTICIPATION

There are no fees for participating and receiving CE credit for this activity. In order to obtain your certificate for the mentioned accreditation, participants need to successfully complete the associated pre/post activities and evaluation. Your certificate will be provided as a downloadable file.

DISCLAIMER

Med Learning Group makes every effort to develop CE activities that are science based. This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making expertise before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact Med Learning Group at [email protected]

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information at www.medlearninggroup.com/privacy-policy/

AMERICANS WITH DISABILITIES ACT

Event staff will be glad to assist you with any special needs (eg, dietary, physical, etc). Please contact Med Learning Group prior to participating at [email protected]

RELEASED DATE: August 21, 2025
EXPIRATION DATE: August 21, 2026

Copyright © 2025 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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