Caregiver Introduction

Hello, my name is Jean. I’m 34 years old and my son, Daniel, just turned 11 years old this past Thursday. Daniel was diagnosed with EoE over a year ago and we have tried different therapies to help him, but nothing has worked so far. I am here today because I’m concerned about Daniel’s poor nutrition because he has trouble swallowing. He has become a very slow eater, not finishing most of his meals as he always complains of feeling full quickly. He has not been gaining weight. Daniel was given a proton pump inhibitor a year ago after his diagnosis by a pediatric gastroenterologist, but he continued to have trouble swallowing. His specialist did an upper endoscopy while on the acid blocker medicine, which showed that he still had EoE. He then went on a strict diet but he was very picky, and refused to eat foods different from what he was used to. We had to stop the diet after 5 weeks. He still has not gained back all the weight he lost. At his last visit with the specialist 3 months ago, he was prescribed a liquid steroid to swallow, but I still don’t see much difference. I would like to discuss what other options there are for Daniel. Follow the prompts on your tablet to join me for a part of the discussion.

Question #1

At your last visit, Daniel had been prescribed a liquid steroid to help reduce the inflammation and make it easier to eat. It’s been a full 3 months; how is his swallowing since taking the steroids?

Answer

Question #2

It can be; it may mean acid reflux symptoms, which can also occur in children with EoE. Is he still taking the acid blocker he was prescribed previously?

Answer

Question #3

There are different approved therapies for children with EoE; the steroid prescribed at Daniel’s last visit was one of them. But with no improvement, there may be other options.

Answer

Question #4

Hmmm; besides my concern about Daniel’s weight, food may be getting stuck with swallowing. I’ll refer him to his gastroenterologist to check for esophageal inflammation and narrowing. Also, I’d like him to see a dietician to help with weight gain.

Answer

Question #5

No, but children his age and older are more likely to experience food impaction. The gastroenterologist may want to look in Daniel’s esophagus with an endoscope and assess treatment options.

Answer

Question #6

Dilating a narrowed esophagus can ease food passage, but that’s a temporary solution; esophageal inflammation needs to be reduced. Another type of medication called immunotherapy targets specific immune system signals to reduce inflammation in EoE. Have you heard of immunotherapy?

Answer

Question #7

Potentially! Some medications are still in development, but dupilumab is approved for kids 1 and older with EoE, and can be injected at home. Research showed decreased eosinophils and reduced EoE symptoms, regardless of treatments they’ve taken in the past.

Answer

Question #8

It is called a biologic. It is used for several conditions relating to type 2 inflammation, including EoE, asthma, eczema, rhinosinusitis and others. These occur through a common pathway; many medications are being developed to target this inflammation.

Answer

Question #9

There have been reports of injection site pain, upper respiratory tract infection, joint pain, headache, and viral infections; however, this medication has been found to be quite effective. Based on his weight, he would need an injection every 2 weeks.

Answer

This activity is provided by Med Learning Group.
This program is supported by an independent educational grant from Regeneron Pharmaceuticals, Inc. and Sanofi.
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