New Clinical Advances in the Management of Motor Complications Associated with Advanced Parkinson’s Disease

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Hubert H. Fernandez, MD
James and Constance Brown Family Endowed Chair in Movement Disorders
Professor of Medicine (Neurology)
Cleveland Clinic Lerner College of Medicine
Chair/Director, Center for Neuro-Restoration
Cleveland Clinic
Cleveland, OH


This enduring activity will cover the treatment and management of patients with Parkinson’s disease (PD).


This activity is intended for US-based neurologists and primary care providers involved in the management of patients with PD, such as internists, family physicians, physician assistants, nurses, nurse practitioners, social workers, physical therapists, occupational therapists, and speech and language pathologists.


Upon completion of the program, attendees should be able to:

  • Review the constellation of symptoms that may fail to respond to levodopa treatment
  • Describe clinical trial evidence supporting the use of interventional therapeutic approaches in the management of PD based on different patient factors
  • List the steps required to restore dopaminergic tone in patients with PD
  • Discuss strategies for comprehensive care and disease management planning, particularly for patients with comorbid conditions


Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
This CME activity was planned and produced in accordance with the ACCME Essentials.


Med Learning Group designates this enduring activity for a maximum of 1.00 AMA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.

Nursing Credit Information
This program would be beneficial for nurses involved in the treatment and management of patients with PD.

CNE Credits:
1.0 ANCC Contact Hour(s)

CNE Accreditation Statement:
Ultimate Medical Academy/CCM is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.
Awarded 1.0 contact hour(s) of continuing nursing education of RNs and APNs.


In accordance with the Accreditation Council for Continuing Medical Education (ACCME)
Standards for Commercial Support, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in a MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.


Hubert H. Fernandez, MD — In the last year, Dr. Fernandez has disclosed the following:

Grants/Research Support: Dr. Fernandez has received research support from Abbvie, Acadia, Teva, Biotie/Acorda Therapeutics, Civitas, Kyowa/Prostrakan, Michael J. Fox Foundation, Movement Disorders Society, NIH/NINDS, Parkinson Study Group, Rhythm, Synosia, but has no owner interest in any pharmaceutical company.

Honoraria: Dr. Fernandez has received honoraria from Prime Education Inc. International Parkinson and Movement Disorders Society, Carling Communications, Medscape, as a speaker in CME events. Dr. Fernandez has received honoraria from AbbVie, Biogen, GE Health Care, Inventiv, Kyowa Hakko Kirin, Lundbeck, Medscape, Merz Pharmaceuticals, Voyager, Sunovion, and Pfizer Pharmaceuticals, as a consultant.

Royalty: Dr. Fernandez has received royalty payments from Demos Publishing for serving as a book author/editor.

Contractual Services: The Cleveland Clinic has a contract with Teva for Dr. Fernandez’ role as a Co-Principal Investigator in SD-809 Tardive Dyskinesia global studies. Dr. Fernandez also serves as a member of the publication committee for Acorda Pharmaceuticals but does not receive any personal compensation for these.

Other: Dr. Fernandez has received a stipend from International Parkinson and Movement Disorders Society for serving as Medical Editor of the MDS Web Site.

CME Content Review
The content of this activity was independently peer reviewed.

The reviewer of this activity has nothing to disclose.

CNE Content Review
The content of this activity was peer reviewed by a nurse.

The reviewer has nothing to disclose.

The staff, planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

Matthew Frese, General Manager of Med Learning Group has nothing to disclose.
Christina Gallo, SVP of Educational Development for Med Learning Group has nothing to disclose.
Flavia Piazza, PhD, VP of Medical and Scientific Services for Med Learning Group has nothing to disclose.
Lauren Welch, MA, VP of Accreditation and Outcomes for Med Learning Group has nothing to disclose.
Melissa A. Johnson, Sr. Program Manager for Med Learning Group has nothing to disclose.


Med Learning Group requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

During the course of this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.


There are no fees for participating and receiving CME/CNE credit for this enduring activity. To receive CME/CNE credit participants must:
1. Read the CME/CNE information and faculty disclosures.
2. Participate in the enduring activity.
3. Submit the evaluation form to Med Learning Group.

You will receive your certification via email within 30 days.


Med Learning Group makes every effort to develop CME activities that are scientifically based. This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact: Med Learning Group at

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information at:

RELEASE DATE: July 31, 2018

EXPIRATION DATE: July 31, 2019

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Participation Statement
This educational activity provides training necessary for licensed attendees to maintain state licensing requirements. The tuition for this educational activity is subsidized in part by unrestricted educational grants, including for those attendees who have successfully completed the state licensing requirements for their respective fields. This subsidy is reflected in the registration fees for this activity.

Copyright © 2018 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.