Evaluating and Managing Ocular Toxicities and Other Potential Adverse Events in the Management of Relapsed/Refractory Multiple Myeloma


Amrita Krishnan, MD
Director of the Judy and Bernard Briskin Center for Multiple Myeloma Research
Professor, Department of Hematology & Hematopoietic Cell Transplantation
Chief, Division of Multiple Myeloma
Department of Hematology and Hematopoietic Cell Transplantation
City of Hope Cancer Center
Duarte, CA


This enduring TeleECHO program will explore the management of ocular toxicities and other adverse events related to treatment of relapsed and refractory multiple myeloma (RRMM). A brief didactic presentation will discuss how and why these adverse events occur. The importance of Risk Evaluation and Mitigation Strategy (REMS) programs for monitoring your patients for corneal changes and other effects of later-line therapy for multiple myeloma will also be presented. Interactive case studies will illustrate strategies for choosing therapy and for managing treatment-related adverse events in the RRMM setting.


This activity is designed to meet the educational needs of multiple myeloma specialists, general oncologists, oncology nurses, clinical pharmacists, and ophthalmologists. Through participation in this programming, the audience will be better able to manage potential adverse events associated with later-line management of multiple myeloma, including potential ocular adverse events, in an interdisciplinary fashion, consistent with REMS educational requirements.


Upon the completion of this program, attendees should be able to:

  • Summarize the mechanism of therapies in management of heavily relapsed/refractory multiple myeloma and how therapeutic mechanisms relate to potential adverse events
  • Recognize challenges in identification of potential adverse events in multiple myeloma, including corneal adverse events, and evaluate best practice for detection and management
  • Evaluate the benefits and potential adverse events associated with later-line multiple myeloma therapy, including corneal adverse events, in the context of REMS programs


Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

This CME activity was planned and produced in accordance with the ACCME Essentials.


Med Learning Group designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.


Purpose: This program would be beneficial for nurses involved in the care of patients with multiple myeloma.
CNE Credits: 1.0 ANCC Contact Hour.


Ultimate Medical Academy/Complete Conference Management (CCM) is accredited as a provider of nursing continuing professional education development by the American Nurses Credentialing Center’s Commission on Accreditation.

Awarded 1.0 contact hour of continuing nursing education of RNs and APNs.


In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support, educational programs sponsored by Med Learning Group must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in an MLG-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.


Dr. Krishnan has received consulting fees from Bristol Myers Squibb, GlaxoSmithKline, Pfizer, Janssen, Sanofi, Sutro Biopharma, Inc. and zPREDICTA; she has also served on the speakers’ bureau for Amgen, Bristol Myers Squibb, and GlaxoSmithKline. She holds stock in Bristol Myers Squibb and serves on the scientific advisory board for Sutro Biopharma, Inc. and zPREDICTA.

CME Content Review

The content of this activity was independently peer reviewed.
The reviewer of this activity has nothing to disclose.

CNE Content Review

The content of this activity was peer reviewed by a nurse reviewer.

Douglas Cox, MSN, MHA, RN
Ultimate Medical Academy/CCM – Lead Nurse Planner

The reviewer of this activity has nothing to disclose.

Staff Planners and Managers

The staff, planners, and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:

  • Matthew Frese, MBA, General Manager of Med Learning Group, has nothing to disclose.
  • Christina Gallo, SVP, Educational Development for Med Learning Group, has nothing to disclose.
  • Angela Davis, MD, Director, Medical & Scientific Services for Med Learning Group has nothing to disclose.
  • Lauren Welch, MA, VP, Accreditation and Outcomes for Med Learning Group, has nothing to disclose.
  • Jessica McMullen, MPH, Program Manager for Med Learning Group, has nothing to disclose.
  • Daniel DaSilva, Accreditation and Outcomes Coordinator for Med Learning Group, has nothing to disclose.
  • Douglas Cox, MSN, MHA, RN, UMA/CCM – LNP, has nothing to disclose.


Med Learning Group requires that faculty participating in any CME activity disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

During this lecture, the faculty may mention the use of medications for both FDA-approved and non-approved indications.


There are no fees for participating and receiving CME credit for this enduring activity. To receive CME/CNE credit participants must:

  1. Read the CME/CNE information and faculty disclosures.
  2. Participate in the enduring activity.
  3. Complete the online post-test and evaluation.

You will receive your certificate as a downloadable file.


Med Learning Group makes every effort to develop CME activities that are science based.
This activity is designed for educational purposes. Participants have a responsibility to use this information to enhance their professional development in an effort to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision making before applying any information, whether provided here or by others, for any professional use.

For CME questions, please contact Med Learning Group at [email protected].

Contact this CME provider at Med Learning Group for privacy and confidentiality policy statement information at http://medlearninggroup.com/privacy-policy/


Staff will be glad to assist you with any special needs. Please contact Med Learning Group prior to participating at [email protected]


Copyright © 2022 Med Learning Group. All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of Med Learning Group is prohibited.

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Med Learning Group, a division of Ultimate Medical Academy, is a full-service accredited medical education company with commendation. Med Learning Group focuses on developing and implementing continuing education that improves healthcare practitioners’ ability to provide optimal care to their patients. Our goal is to provide high-quality education that is designed to deliver the highest level of outcomes for not only the practitioner, but also the patient. Med Learning Group has expertise in developing both live and online activities that are innovative, case-based, interactive and patient-centric in nature.

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